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KMID : 0370019910050000087
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Chung-Ang Journal of Pharmacal Sciences
1991 Volume.5 No. 0 p.87 ~ p.99
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Hypoglycemic Agents from Medicinal Plants
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Abstract
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Hypoglycemic activity of fractions and asarones of Bambusae caulis in Taeniam were studied in normal and streptozotocin-induced hyperglycemic mice.
The results were as follows :
1. Asarones were a major principle(0.02%) of essential oil from Bambusae caulis in Taeniam. They were consist of β-(59.16%), γ-(26.03%) and α-asarone(14.81%)
2. The hexane, chloroform, ethyl acetate, butanol and water fractions of Bambusae caulis in Taeniam at the oral dose of 100㎎/㎏ decreased significantly the blood glucose, body weight loss and water cosumption in hyperglycemic mice. Their ethyl acetate, butanol and water fractions at th oral dose of 100㎎/㎏ decreased significantly the blood glucose in normal mice.
3. The mixture of asarones from Bambusae caulis in Taeniam at the oral dose of 20㎎/㎏ decreased significantly the blood glucose in normal mice and hyperglycemic mice. Therefore asarones was one of hypoglycemic principles of Bambusae caulis in Taeniam.
4. Bambusae caulis in Taeniam has the hypoglycemic activity because of improving the degenerative change of β-cell in Langerhan´s islet by streptozotocin.
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